Warning signs of a fragility fracture
(menopausal women, men age 50-64 yr*)
- Chronic pain1
-
Reduced mobility
- Fragility fractures have had lasting deficits on patients’ post-fracture ability to move independently.2†
-
Loss of height1
-
Among men and women with the most severe kyphosis, ~36% have
underlying vertebral fractures3‡
- – Vertebral Fracture Assessment – An incident fracture can be diagnosed if any of 3 vertebral heights (anterior, middle or posterior) decreased by more than 20% and by at least 4 mm compared with the previous film4§
-
Among men and women with the most severe kyphosis, ~36% have
underlying vertebral fractures3‡
- Disability1
- Disability1
Canadian Multicentre Osteoporosis Study (CaMos), a prospective, 10-year study of patients with osteoporosis; used health utilities index (HUI) since its inception. Data has shown that men with hip fractures had substantial deficits in mobility: HUI2 score: -0.20 from baseline (0.981 [0.08]) to year 5.2†
Clinical risk factors of a fragility fracture
(menopausal women, men age 50-64 yr*)
- Personal history of a fragility fracture after age 40 yr5
- A previous fracture denotes more accurately a previous fracture in adult life occurring spontaneously, or a fracture arising from trauma which, in a healthy individual, would not have resulted in a fracture6
- Parental hip fracture5
- Current smoking5
- Prolonged use of glucocorticoids5¶
- Rheumatoid arthritis5
- An osteoporosis diagnosis or a secondary osteoporosis diagnosis (the patient has a disorder strongly associated with osteoporosis such as type I (insulin dependent) diabetes, osteogenesis imperfecta in adults, untreated long-standing hyperthyroidism, hypogonadism or premature menopause (<45 years), chronic malnutrition, or malabsorption and chronic liver disease)5,6
- Use of other high-risk medications5**
- Vertebral fracture or osteopenia identified on radiography
- High alcohol intake (3 or more units of alcohol daily)5,6
- Low body weight (< 60 kg) or major weight loss (> 10% of body weight at age 25 yr)5
A fracture is one of the most significant risk factors for predicting future fracture7
Risk of another fracture within 1 year:
After vertebral fracture:
20% risk7
After hip fracture:
5%-10% risk7
Imminent fracture risk
It has been reported that the majority of subsequent fragility fractures tended to occur within the initial 2 years after an incident fracture.8
16%
after hip fracture††
(index fractures n=31,613)
20%
after forearm
(radius or ulna) fracture††
(index fractures n=4,828)
19%
after humerus fracture††
(index fractures n=13,237
CLOSE THE OSTEOPOROSIS CARE GAP:
Prevent fragility fractures and their negative consequences5